If you can, avoid interstates at all costs. The higher speeds will kill your MPG. go very slow up the mountains when possible (like 30 MPH max). Be sure to plan lots of extra time to go slower. On our trip to Oregon we didn't have much time and had to go fast, killed my MPG's.
Stop by the Evergreen Aviation Museum in McMinville OR (near Portland) and see the Spruce Goose (
Evergreen Aviation & Space Museum). Pictures do not do it justice.
If you can take the time to hike some of the coastal trails in Oregon, do it by all means. Its very scenic. Take a wind-breaker or a light jacket as it can be very windy there.
I can't think of anything else right now.