I should have posted this reply before your trip... anyway, better late than never...
From my experience, on long trip, I achieve better mileage without cruise control. I get 2-3 more mpg overall. By "Manual control", you can monitor the road, and make better use of relief. However, it's a bit tiresome for long distance, so it's up to you to use or not.
Also, I figured out I can get another additional 2-3 mpg by using good pulse & glide techniques. I have a scangauge II, which helps a lot to put the accel pedal at the right place. I set the SGII for viewing the TPS (Throttle Position), For a 65mph speed, I set my foot at 22-23deg (not sure if my SGII is well calibrated, at rest I'm at 17deg... but anyway), so I first bring it to 68-69mph, using a 26-27deg TPS, which is very gentle, then I glide at 22-23deg TPS until I reach a 64-62mph range, and restart a pulse. If the road is flat, it can be some good miles glide each time. On my glide, I'm at about 61-62mpg, on my pulse, I'm about 42-43mpg. Overall, I would currently yield about 51-52mpg (winter conditions)
If you are on a slower highway (say 60 instead of 70), the same pulse & glide can be done with ~3deg less throttle. On my daily commute, I would try to set a 63-64mph pulse and 55-56mph glide. Pulse would be around 47-48mpg, glide 68-70mpg. This yield another +3-4mpg overall. I had 55-56mpg tanks this fall, best tank being 58.6mpg so far, but this is before getting the SGII.
Note 1 : I developed this refinement with the winter gas blend as I got my SGII only few weeks ago. I understood and practiced the P&G before getting the SGII, so I was already getting good mpg last summer with lifetime around 54.3mpg, but I think this additional level of feedback the SGII gives with the TPS will help increasing my mpg. Cannot wait next summer to confirm…
Note 2 : This is not “normal driving”, it’s pretty extreme in my mind and sometime annoying. My advice is to stay in the right lane, be aware of the drivers around and do not push the technique too hard if the traffic is dense and does not allow safe driving conditions.
Note 3 : I’m open to any feedback to improve my P&G technique,

or any other hypermiling technique. As you see, I fall in the category who drive and accept the I2 willing to change driving style to yield better and better mpg