The trade-off always seems to be that you sacrifice mpg for smooth and quiet.
Are you running your tires pumped up? Putting them at the Honda pressures (38,35) makes is smoother and quieter, but you lose mpg.
Quiet can be worked on by sound insulation pretty easily.
Smoothness is harder without losing mpg. I would start by just experimenting with tire pressures starting with going to the 38,35 or even a small bit lower.
Other folks might comment if they switched tires completely to other brands...??